SPACE WEATHER EFFECTS ON TRANSPORTATION SYSTEMS: A REVIEW OF CURRENT UNDERSTANDING AND FUTURE OUTLOOK


Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline telemarkskongen flue and noradrenaline.Here, the authors present the cryo-EM structures of full-length human TH in the apo form and bound with DA, grandpas best as well as the structure of Ser40 p

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Unlocking phenotypic plasticity provides novel insights for immunity and personalized therapy in lung adenocarcinoma

Background: Unlocking phenotype plasticity (UPP) has been shown to have an essential role in the mechanism of tumor development and therapeutic response.However, the clinical significance of unlocking phenotypic plasticity in patients with lung adenocarcinoma is unclear.This study aimed to explore the roles of unlocking phenotypic plasticity in imm

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